Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DIRC1 |
| Gene Name: | DIRC1 |
| Protein Full Name: | Disrupted in renal carcinoma protein 1 |
| Alias: | Disrupted in renal cancer protein |
| Mass (Da): | 11440 |
| Number AA: | 104 |
| UniProt ID: | Q969H9 |
| Locus ID: | 116093 |
| COSMIC ID: | DIRC1 |
| Gene location on chromosome: | 2q33 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19603 |
| Percent of cancer specimens with mutations: | 0.13 |
| Mutations observed as inherited: | Familial clear cell renal cancer |
| Deregulated in translocations: | t(2;3)(q33;q21) |
| Normal role description: | Function unknown. Disruption of the gene, due to the translocation t(2;3)(q33;q21), is associated with familial clear cell renal cancer. |