Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TP53INP1 |
| Gene Name: | TP53INP1 |
| Protein Full Name: | Tumor protein p53-inducible nuclear protein 1 |
| Alias: | Stress-induced protein;p53-dependent damage-inducible nuclear protein 1 |
| Mass (Da): | 27366 |
| Number AA: | 240 |
| UniProt ID: | Q96A56 |
| Locus ID: | 94241 |
| COSMIC ID: | TP53INP1 |
| Gene location on chromosome: | 8q22.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19904 |
| Percent of cancer specimens with mutations: | 0.18 |
| Normal role description: | TP53INP1 is a tumour suppressor gene induced with different stress conditions. TP53INP1 overexpression leads to cell cycle arrest (G1 phase) and p53-dependent or independent apoptosis. TP53INP1 interacts with p53 and two kinases (HIPK2, and PKCd). It is phosphrylated and translocates into the nucleas to continue apoptosis signalling pathways. Loss of function correlates with increasing propensity towards oncogenesis. |