Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | EXOC4 |
| Gene Name: | EXOC4 |
| Protein Full Name: | Exocyst complex component 4 |
| Alias: | Exocyst complex component Sec8; KIAA1699; MGC27170; REC8; SEC8; SEC8L1; Sec8p |
| Mass (Da): | 110498 |
| Number AA: | 974 |
| UniProt ID: | Q96A65 |
| Locus ID: | 60412 |
| COSMIC ID: | EXOC4 |
| Gene location on chromosome: | 7q31 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19809 |
| Percent of cancer specimens with mutations: | 0.9 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Broad distribution of mutation sites with some point mutations and 1 deletion , but no complex mutations or insertions. |
| Normal role description: | EXOC4 is invoved in exocyst complex. Its role is targeting of exocytic vesicles to docking sites at the plasma membrane. It may also have a role in actin cytoskeleton rearrangement, vesicle transport machinary and epithelial cell surface polarity. |