Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MSI2 |
| Gene Name: | MSI2 |
| Protein Full Name: | RNA-binding protein Musashi homolog 2 |
| Number AA: | 328 |
| UniProt ID: | Q96DH6 |
| Locus ID: | 124540 |
| COSMIC ID: | MSI2 |
| Gene location on chromosome: | 17q22; 17q23.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19535 |
| Percent of cancer specimens with mutations: | 0.25 |
| Deregulated in translocations: | Chronic myeloid leukemia (CML). Fusion partner is HOXA9. |
| Normal role description: | MSI2 is an RNA binding protein and may function in regulating mRNA molecules in the cell. MSI2 may have a role in regulating stem cells of the CNS. A translocation event of the MSI2 gene locus may result in a fusion protein with HOXA9. The MSI2-HOXA9 fusion protein has been implicated in chronic myeloid leukemia (CML). |