Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SIRT1 |
| Gene Name: | SIRT1 |
| Protein Full Name: | NAD-dependent deacetylase sirtuin-1 |
| Alias: | HSIR2; HSIRT1; NAD-dependent deacetylase sirtuin 1; SIR1; SIR2L1; SIR2-like protein 1; Sirtuin (silent mating type information regulation 2) 1; Sirtuin 1 |
| Mass (Da): | 81681 |
| Number AA: | 747 |
| UniProt ID: | Q96EB6 |
| Locus ID: | 23411 |
| COSMIC ID: | SIRT1 |
| Gene location on chromosome: | 10q21.3 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.38 |
| Normal role description: | De-acetylates many protein targets. SIRT1 contains nuclear localization signal but also functions to regulate metabolic processes in the cytoplasm. SIRT1 is implicated in histone de-acetylation and therefore activation/repression of different genes. For example, it protects against p53-dependent apoptosis but also functions as a cell-cycle checkpoint protein via FOXO1 and FOXO4 interaction; inhibits NF-kB signalling pathways. These varied roles lead to both tumour promotion and inhibition in different cancer systems |