Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | HSPBAP1 |
| Gene Name: | HSPBAP1 |
| Protein Full Name: | HSPB1-associated protein 1 |
| Alias: | 27 kDa heat shock protein-associated protein 1;Protein associated with small stress protein 1 |
| Mass (Da): | 55167 |
| Number AA: | 488 |
| UniProt ID: | Q96EW2 |
| Locus ID: | 79663 |
| COSMIC ID: | HSPBAP1 |
| Gene location on chromosome: | 3q21.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.38 |
| Mutations observed as inherited: | Familial renal cell cancer |
| Deregulated in translocations: | t(2;3)(q35;q21): DIRC3-HSPBAP1 |
| Normal role description: | HSPBAP1 protein binds hsp27, a small heat shock protein, specifically. It contains transcription factor motifs of the jumonji, jmjC family. May be involved in cellular stress response and chromatin remodeling. |