Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DNAJA3 |
| Gene Name: | DNAJA3 |
| Protein Full Name: | DnaJ homolog subfamily A member 3, mitochondrial |
| Alias: | DnaJ protein Tid-1; Hepatocellular carcinoma-associated antigen 57; Tumorous imaginal discs protein Tid56 homolog |
| Mass (Da): | 52538 |
| Number AA: | 480 |
| UniProt ID: | Q96EY1 |
| Locus ID: | 9093 |
| COSMIC ID: | DNAJA3 |
| Gene location on chromosome: | 16p13.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19780 |
| Percent of cancer specimens with mutations: | 0.31 |
| Normal role description: | Two Isoforms: Isoform 1 increases, whereas isoform 2 suppresses apoptosis. Role in tumour suppression through interaction with oncogenic proteins ErbB2 and p53. Modulates the JAK/STAT pathway. |