Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NEIL1 |
| Gene Name: | NEIL1 |
| Protein Full Name: | Endonuclease 8-like 1 |
| Alias: | DNA glycosylase/ap lyase neil1; DNA-(apurinic or apyrimidinic site) lyase neil1; EC 3.2.2.-; EC 4.2.99.18; Endonuclease viii; Endonuclease viii-like 1; Fpg1; Hfpg1; Neh1; Nei endonuclease viii-like 1; Nei1; Neil1; Nei-like 1 |
| Mass (Da): | 43684 |
| Number AA: | 390 |
| UniProt ID: | Q96FI4 |
| Locus ID: | 79661 |
| COSMIC ID: | NEIL1 |
| Gene location on chromosome: | 15q24.2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20150 |
| Percent of cancer specimens with mutations: | 0.32 |
| Normal role description: | NEIL1 is a DNA glycosylase enzyme involved in removing a damaged nucleobases in DNA to initiate the base excision repair mechanism for damaged DNA. NEIL1 also possesses apurinic/apyrimidinic (AP) lyase activity to introduce a DNA strand break which classifies NEIL1 as a bifunctional glycosylase. Mutations leading to decreased activity or reduced expression of NEIL1 has been implicated in the development of some gastric cancers. NEIL1 can be classified as a tumour suppressor protein. |