Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SIPA1 |
| Gene Name: | SIPA1 |
| Protein Full Name: | Signal-induced proliferation-associated protein 1 |
| Alias: | GTPase-activating protein Spa-1; Signal-induced proliferation-associated protein 1: GTPase-activating protein Spa-1: p130 SPA-1 |
| Mass (Da): | 112149 |
| Number AA: | 1042 |
| UniProt ID: | Q96FS4 |
| Locus ID: | 6494 |
| COSMIC ID: | SIPA1 |
| Gene location on chromosome: | 11q13.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 0.52 |
| Normal role description: | SIPA1 is a mitogen induced GTPase activating protein (GAP). SIPA1 has a specific GAP-activity for the Ras-related regulatory proteins, Rap1 and Rap2. Germline muations in this gene are associated with breast cancer metastasis. |