Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PDLIM5 |
| Gene Name: | PDLIM5 |
| Protein Full Name: | PDZ and LIM domain protein 5 |
| Alias: | Enh; Enigma; Enigma-like PDZ and LIM domains protein; LIM; PDLI5; PDZ and LIM domain 5; PDZ and LIM domain protein 5: Enigma homolog: Enigma-like PDZ and LIM domains protein |
| Mass (Da): | 64002 |
| Number AA: | 596 |
| UniProt ID: | Q96HC4 |
| Locus ID: | 10611 |
| COSMIC ID: | PDLIM5 |
| Gene location on chromosome: | 4q22 |
| Number of cancer specimens: | 19650 |
| Percent of cancer specimens with mutations: | 0.5 |
| Commentary on involvement of protein in cancer: | May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses |