Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PAWR |
| Gene Name: | PAWR |
| Protein Full Name: | PRKC apoptosis WT1 regulator protein |
| Alias: | PAR4; Par-4; PRKC, apoptosis, WT1, regulator; Prostate apoptosis response 4 protein; Prostate apoptosis response protein 4; Prostate apoptosis response protein PAR-4; Prostate apoptosis response-4 protein; Transcriptional repressor PAR4; WT1-interacting protein |
| Mass (Da): | 36568 |
| Number AA: | 340 |
| UniProt ID: | Q96IZ0 |
| Locus ID: | 5074 |
| COSMIC ID: | PAWR |
| Gene location on chromosome: | 12q21.2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBIT |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.17 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | PAWR is a pro-apoptotic protein that can sensitize tumour cells to apoptotic stimuli and cause regression of tumors in animal models. It induces apoptosis by activating the Fas death receptor pathway and inhibit NF-kB transcription, or by inhibiting the prosurvival protein Bcl-2 and downregulating ERK2 expression. PAWR can also suppress Ras expression. |