Cancer Protein Description

This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.


Protein Name: LOXL4
Gene Name: LOXL4
Protein Full Name: Lysyl oxidase homolog 4
Alias: Lysyl oxidase-like protein 4;Lysyl oxidase-related protein C
Mass (Da): 84483
Number AA: 756
UniProt ID: Q96JB6
Locus ID: 84171
COSMIC ID: LOXL4
Gene location on chromosome: 10q24.2
Cancer protein type: UNCLEAR
Effect of cancer mutation on protein: UNCLEAR
Effect of active protein on cancer: UNCLEAR
Number of cancer specimens: 19718
Percent of cancer specimens with mutations: 0.61
Mutations observed as inherited: NA
Found in amplified chromosomal regions in human cancers: 10q24
Deregulated in translocations: NA
Deregulated by viral insertion: NA
Transduced into viral genome: NA
Gene undergoes hypermethylation: NA
Normal role description: LOXL4 is a lysyl oxidase that may modulate the formation of collagenous extracellular matrix, especially elastin. It may have roles in developmental regulation, senescence, tumour suppression, cell growth control and chemotaxis, but its mechanisms are unknown. It is expressed in highly invasive breast cancer cells, but not in non-metastatic cells.


Provide the gene name, protein name, UniProt ID or Locus ID as a search term. Click on Retrieve Info button to obtain information on the selected cancer protein.