Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
Protein Name: | LOXL4 |
Gene Name: | LOXL4 |
Protein Full Name: | Lysyl oxidase homolog 4 |
Alias: | Lysyl oxidase-like protein 4;Lysyl oxidase-related protein C |
Mass (Da): | 84483 |
Number AA: | 756 |
UniProt ID: | Q96JB6 |
Locus ID: | 84171 |
COSMIC ID: | LOXL4 |
Gene location on chromosome: | 10q24.2 |
Cancer protein type: | UNCLEAR |
Effect of cancer mutation on protein: | UNCLEAR |
Effect of active protein on cancer: | UNCLEAR |
Number of cancer specimens: | 19718 |
Percent of cancer specimens with mutations: | 0.61 |
Mutations observed as inherited: | NA |
Found in amplified chromosomal regions in human cancers: | 10q24 |
Deregulated in translocations: | NA |
Deregulated by viral insertion: | NA |
Transduced into viral genome: | NA |
Gene undergoes hypermethylation: | NA |
Normal role description: | LOXL4 is a lysyl oxidase that may modulate the formation of collagenous extracellular matrix, especially elastin. It may have roles in developmental regulation, senescence, tumour suppression, cell growth control and chemotaxis, but its mechanisms are unknown. It is expressed in highly invasive breast cancer cells, but not in non-metastatic cells. |