Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SLC45A3 |
| Gene Name: | SLC45A3 |
| Protein Full Name: | Solute carrier family 45 member 3 |
| Alias: | IPCA-2; IPCA6; IPCA-6; IPCA-8; PCANAP2; PCANAP6; PCANAP8; Prostate cancer-associated 6; Prostein; PRST; S45A3; Solute carrier family 45, member 3 |
| Mass (Da): | 59323 |
| Number AA: | 553 |
| UniProt ID: | Q96JT2 |
| Locus ID: | 85414 |
| COSMIC ID: | SLC45A3 |
| Gene location on chromosome: | 1q32.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20220 |
| Percent of cancer specimens with mutations: | 0.51 |
| Normal role description: | SLC45A3's function is relatively unkown; though it likely part of the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family. It seems to have prostate specific expression, in both normal and cancerous prostates. Missenes and deletion mutations have been found in ovarian tumors. |