Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | USP47 |
| Gene Name: | USP47 |
| Protein Full Name: | Ubiquitin carboxyl-terminal hydrolase 47 |
| Alias: | Ubiquitin specific peptidase 47; Ubiquitin thioesterase 47; UBP47 |
| Mass (Da): | 157268 |
| Number AA: | 1375 |
| UniProt ID: | Q96K76 |
| Locus ID: | 55031 |
| COSMIC ID: | USP47 |
| Gene location on chromosome: | 11p15.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20150 |
| Percent of cancer specimens with mutations: | 0.74 |
| Normal role description: | USP47 is a Ubiquitin-specific protease. It functions by de-ubiquitinating mono-ubiquitinated DNA polymerase beta (POLB), which thereby stabilizes POLB -- involved in base-excision repair (BER). Missense mutations in skin and upper aerodigestive tract (mouth and larynx) tumors. |