Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ZNF521 |
| Gene Name: | ZNF521 |
| Protein Full Name: | Zinc finger protein 521 |
| Alias: | Early hematopoietic zinc finger protein; LYST-interacting protein 3 |
| Mass (Da): | 147848 |
| Number AA: | 1311 |
| UniProt ID: | Q96K83 |
| Locus ID: | 25925 |
| COSMIC ID: | ZNF521 |
| Gene location on chromosome: | 18q11.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20000 |
| Percent of cancer specimens with mutations: | 2.14 |
| Deregulated in translocations: | t(9;18)(p13;q11.2): PAX5-ZNF521 (acute lymphoblastic leukemia) |
| Normal role description: | Can act as transcriptional activator and repressor. Involved in regulation of the immature compartment of the hematopoietic system and BMP signalling. Translocation associated with acute lymphoblastic leukemia, resulting in the fusion oncoprotein PAX5-ZNF521. |