Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SCYL1 |
| Gene Name: | SCYL1 |
| Protein Full Name: | N-terminal kinase-like protein |
| Alias: | Coated vesicle-associated kinase of 90 kDa; SCY1-like protein 1; Telomerase regulation-associated protein; Telomerase transcriptional element-interacting factor; Teratoma-associated tyrosine kinase |
| Mass (Da): | 89631 |
| Number AA: | 808 |
| UniProt ID: | Q96KG9 |
| Locus ID: | 57410 |
| COSMIC ID: | SCYL1 |
| Gene location on chromosome: | 11q13 |
| Number of cancer specimens: | 19828 |
| Percent of cancer specimens with mutations: | 0.45 |
| Commentary on involvement of protein in cancer: | Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro. Ref.8 Ref.11 Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region. |