Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MARK4 |
| Gene Name: | MARK4 |
| Protein Full Name: | MAP/microtubule affinity-regulating kinase 4 |
| Alias: | FLJ90097; KIAA1860; Kinase MARK4; MARKL1; MARKL1, EC 2.7.11.1; Nbla00650 |
| Mass (Da): | 82520 |
| Number AA: | 752 |
| UniProt ID: | Q96L34 |
| Locus ID: | 57787 |
| COSMIC ID: | MARK4 |
| Gene location on chromosome: | 19q13.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19854 |
| Percent of cancer specimens with mutations: | 0.65 |
| Normal role description: | MARK4 is a microtubule affinity-regulating kinase and is associated with the centrosome during mitosis, it may also regulate the cell cycle progression. Mutation in this gene have been found in mouth and ovarian cancer. |