Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | EP400 |
| Gene Name: | EP400 |
| Protein Full Name: | E1A-binding protein p400 |
| Alias: | CAG repeat protein 32; CAGH32; DKFZP434I225; domino; E1A binding protein p400; E1A-binding protein p400; EP400; KIAA1498; KIAA1818; P400; P400 SWI2/SNF2-related protein; TNRC12; trinucleotide repeat-containing gene 12 protein |
| Mass (Da): | 343647 |
| Number AA: | 3124 |
| UniProt ID: | Q96L91 |
| Locus ID: | 57634 |
| COSMIC ID: | EP400 |
| Gene location on chromosome: | 12q24.33 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19627 |
| Percent of cancer specimens with mutations: | 2.53 |
| Transduced into viral genome: | EP400 is a target for the E1A viral oncoprotein transforming activity. |
| Normal role description: | EP400 is part of the NuA4 histone acetyltransferase complex that induces transcriptional activation of select genes by acetylation of nucleosomal histones: H4 and H2A. |
| Commentary on involvement of protein in cancer: | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. |