Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DACH2 |
| Gene Name: | DACH2 |
| Protein Full Name: | Dachshund homolog 2 |
| Mass (Da): | 65323 |
| Number AA: | 599 |
| UniProt ID: | Q96NX9 |
| Locus ID: | 117154 |
| COSMIC ID: | DACH2 |
| Gene location on chromosome: | Xq21.2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBIT |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 0.95 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | DACH2 is a transcription factor that is mostly expressed during embryonic development and is involved in organogenesis regulation. It acts as a corepressor of SIX6 in regulating proliferation by repressing cyclin-dependent kinase inhibitors such as the p27Kip1 promoter. Tissues affected by this developmental regulation include the retina and muscle. This gene can be inactivated by DNA methylation. |