Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PVRL4 |
| Gene Name: | PVRL4 |
| Protein Full Name: | Poliovirus receptor-related protein 4 |
| Alias: | Ig superfamily receptor LNIR; LNIR; Nectin-4; Poliovirus receptor-related 4; PRR4; PVRL4 |
| Mass (Da): | 55454 |
| Number AA: | 510 |
| UniProt ID: | Q96NY8 |
| Locus ID: | 81607 |
| COSMIC ID: | PVRL4 |
| Gene location on chromosome: | 1q23.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.63 |
| Normal role description: | Belongs to the family of nectin adhesion molecules. Involved in cell adhesion and migration. Binds Nectin-1 through IgV domain interaction. Associated with tumour cell migration in breast carcinoma. Soluble form found in patients sera is a marker for disease progression. |