Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | FCRL5 |
| Gene Name: | FCRL5 |
| Protein Full Name: | Fc receptor-like protein 5 |
| Alias: | BXMAS1; CD307; Fc receptor-like 5; FCRH5; immunoglobulin receptor translocation-associated gene 2; IRTA2 |
| Mass (Da): | 106483 |
| Number AA: | 977 |
| UniProt ID: | Q96RD9 |
| Locus ID: | 83416 |
| COSMIC ID: | FCRL5 |
| Gene location on chromosome: | 1q23.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19691 |
| Percent of cancer specimens with mutations: | 1.35 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Broad distribution of mutation sites with some point mutations , but no complex mutations, insertions or deletions. |
| Found in amplified chromosomal regions in human cancers: | Duplication dup1(q21q32) in Burkitt's lymphoma |
| Normal role description: | FCRL5 is part of the immunoglobulin receptor superfamily and Fc-receptor like family. It is involved in B cell development, lymphomagenesis, differentiation of peripheral lymphoid organs and possible regulation of marginal zone B-cells. A duplication of the gene has been found in Burkitt's lymphoma. |