Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CITED4 |
| Gene Name: | CITED4 |
| Protein Full Name: | Cbp/p300-interacting transactivator 4 |
| Alias: | MSG1-related protein 2 |
| Mass (Da): | 18569 |
| Number AA: | 184 |
| UniProt ID: | Q96RK1 |
| Locus ID: | 163732 |
| COSMIC ID: | CITED4 |
| Gene location on chromosome: | 1p34.2; 1p35-p34 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19579 |
| Percent of cancer specimens with mutations: | 0.01 |
| Gene undergoes hypermethylation: | Hypermethylation of the CITED4 promoter has been observed in oligodendroglioma. |
| Normal role description: | CITED4 is a nuclear localized transcriptional co-activator. CITED4 is an effector of growth factor receptors. CITED4 has been found to regulate gene transcription through interaction with CBP and AP-2. Loss of CITED4 function has been implicated in cancer. |