Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RSF1 |
| Gene Name: | RSF1 |
| Protein Full Name: | Remodeling and spacing factor 1 |
| Alias: | HBV pX associated protein 8 large isoform; HBXAP; Hepatitis B virus X-associated protein; P325; Rsf-1; XAP8; XAP8alpha |
| Mass (Da): | 163821 |
| Number AA: | 1441 |
| UniProt ID: | Q96T23 |
| Locus ID: | 51773 |
| COSMIC ID: | RSF1 |
| Gene location on chromosome: | 11q13.5 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 0.93 |
| Found in amplified chromosomal regions in human cancers: | Amplification of 11q13 detected an ovarian cancer cell line, OVCAR3 |
| Normal role description: | RSF1 functions as transcription coactivator when associated with hepatitis B virus X protein (HBX). It represses TNF-alpha induced NF-kappa-B transcription activation. RSF1 functions as a chromatin remodeling and spacing protein when associated with SNF2H. Experiments with ovarian serous carcinoma have demonstrated it is a necessary protein for tumour survival. This gene is predominantly expressed in the most aggressive variants of serous ovarian cancer. |