Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RBM15 |
| Gene Name: | RBM15 |
| Protein Full Name: | Putative RNA-binding protein 15 |
| Alias: | One- twenty two protein; One twenty-two; OTT; OTT1; RBMF; RNA binding motif protein 15 |
| Mass (Da): | 107189 |
| Number AA: | 977 |
| UniProt ID: | Q96T37 |
| Locus ID: | 64783 |
| COSMIC ID: | RBM15 |
| Gene location on chromosome: | 1p13 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20357 |
| Percent of cancer specimens with mutations: | 0.01 |
| Deregulated in translocations: | MAL |
| Normal role description: | RBM15 has implications in suppressing signalling pathways, HOX gene regulation and may also bind RNA by interaction with splicosome. In cancer, dysregulation can lead to oncogenesis. |