Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PPP1R16B |
| Gene Name: | PPP1R16B |
| Protein Full Name: | Protein phosphatase 1 regulatory inhibitor subunit |
| Alias: | ANKRD4; Ankyrin repeat domain 4; Ankyrin repeat domain protein 4; CAAX box TIMAP; KIAA0823; PP16B; Protein phosphatase 1 regulatory inhibitor 16B; Protein phosphatase 1, regulatory (inhibitor) subunit 16B; TGF-beta-inhibited membrane-associated; TGF-beta-inhibited membrane-associated protein; TIMAP |
| Mass (Da): | 63551 |
| Number AA: | 567 |
| UniProt ID: | Q96T49 |
| Locus ID: | 26051 |
| COSMIC ID: | PPP1R16B |
| Gene location on chromosome: | 20q11.23 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19925 |
| Percent of cancer specimens with mutations: | 0.93 |
| Normal role description: | PPP1R16B is a protein-serine/threonine phosphatase regulatory protein. It promotes interaction of PPP1CA with RPSA/LMAR1 resulting in dephosphorylation. It is involved in pulmonary endothelial cell barrier function and filopodia extension. |