Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CSF3R |
| Gene Name: | CSF3R |
| Protein Full Name: | Granulocyte colony-stimulating factor receptor |
| Alias: | CD114 antigen; CSF3R; CSFGR; GCSR |
| Mass (Da): | 92156 |
| Number AA: | 836 |
| UniProt ID: | Q99062 |
| Locus ID: | 1441 |
| COSMIC ID: | CSF3R |
| Gene location on chromosome: | 1p35-p34.3 |
| Number of cancer specimens: | 26163 |
| Percent of cancer specimens with mutations: | 1.13 |
| Commentary on involvement of protein in cancer: | Patients carrying these mutations are at risk for developing myelodysplastic syndromes and/or acute myeloid leukemia.Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface. |