Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MUC4 |
| Gene Name: | MUC4 |
| Protein Full Name: | Mucin-4 |
| Alias: | Ascites sialoglycoprotein;Pancreatic adenocarcinoma mucin;Testis mucin;Tracheobronchial mucin;Ascites sialoglycoprotein 1;Ascites sialoglycoprotein 2 |
| Mass (Da): | 231584 |
| Number AA: | 2169 |
| UniProt ID: | Q99102 |
| Locus ID: | 4585 |
| COSMIC ID: | MUC4 |
| Gene location on chromosome: | 3q29 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19812 |
| Percent of cancer specimens with mutations: | 1.22 |
| Normal role description: | MUC4 is an integral membrane glycoprotein found on the cell surface, although secreted isoforms also exist. It provides lubrication, moisturization, and protection to the epithelial surfaces by trapping foreign particles and preventing them gaining access into the cells.It plays an important role in the protection, differentiation, and renewal of epithelial cells by inducing phosphorylation of ErbB2. It may play a role in tumour progression and growth by repressing apoptosis, and it also has anti-adhesive properties. |
| Commentary on involvement of protein in cancer: | 1 pharyngeal sample was also mutated (mis-sense) |