Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NOTCH4 |
| Gene Name: | NOTCH4 |
| Protein Full Name: | Neurogenic locus notch homolog protein 4 |
| Mass (Da): | 209622 |
| Number AA: | 2003 |
| UniProt ID: | Q99466 |
| Locus ID: | 4855 |
| COSMIC ID: | NOTCH4 |
| Gene location on chromosome: | 6p21.32 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20348 |
| Percent of cancer specimens with mutations: | 1.76 |
| Deregulated by viral insertion: | Mouse mammary tumour virus - Mouse |
| Normal role description: | Receptor related to Notch. It is implicated in cell fate determination, differentiation, proliferaion, apoptosis, vascular devleopment, renal development and hepatic development. Upon ligand binding the released intracellular portion forms a transcription activator complex to regulate gene expression for the mentioned roles above. Overexpression of notch signalling has been implicated in invasive breast cancer and in breast cancer stem cells and is important for uncontrolled growth and development of cancer. |