Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | AGAP2 |
| Gene Name: | AGAP2 |
| Protein Full Name: | Arf-GAP with GTPase, ANK repeat and PH domain-cont |
| Alias: | AGAP-2; ArfGAP with GTPase domain, ankyrin repeat and PH domain 2; CEG1; CENG1; Centaurin-gamma 1; Centaurin-gamma-1; GGAP2; GTP-binding and GTPase-activating protein 2; KIAA0167; Phosphatidylinositol-3-kinase enhancer; PIKE-A |
| Mass (Da): | 124674 |
| Number AA: | 1192 |
| UniProt ID: | Q99490 |
| Locus ID: | 116986 |
| COSMIC ID: | AGAP2 |
| Gene location on chromosome: | 12q14.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19882 |
| Percent of cancer specimens with mutations: | 0.8 |
| Found in amplified chromosomal regions in human cancers: | 12q13-q15 is frequently amplified in brain tumors; this region contains AGAP2 |
| Normal role description: | AGAP2 is part of the centaurin gamma-like family; it functions as an anti-apoptotic factor by activating the Akt pathway, by directly activating PI3K. In this capacity its over expression or increased activity can promote oncogenesis. It has been implicated in glioblastoma formation and breast cancer. |
| Commentary on involvement of protein in cancer: | Further, the tumors derived from smoker express higher incidence of D40 mRNA than the ones from non-smoker. D40 is a member of cancer/testis gene family. |