Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | GPER |
| Gene Name: | GPER |
| Protein Full Name: | G-protein coupled estrogen receptor 1 |
| Alias: | Chemoattractant receptor-like 2;Flow-induced endothelial G-protein coupled receptor 1;G-protein coupled receptor 30;GPCR-BR;IL8-related receptor DRY12;Lymphocyte-derived G-protein coupled receptor;Membrane estrogen receptor |
| Mass (Da): | 42248 |
| Number AA: | 375 |
| UniProt ID: | Q99527 |
| Locus ID: | 2852 |
| COSMIC ID: | GPER |
| Gene location on chromosome: | 7p22.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19603 |
| Percent of cancer specimens with mutations: | 0.33 |
| Normal role description: | Estrogen responsive receptor localized in the membrane of the endoplasmic reticulum. Its activation results in MMP activation, EGF release and transactivation of EGFR. Role in rapid non-genomic signalling events. May not mediate transcription via classic estrogen-response elements. Expression levels of GPER were reported to correlate with tumour size, metastasis and HER2 espression in breast cancer and with survival in endometrial cancer. Estrogen-dependent responses (proliferation and migration) are mediated via GPER in ovarian, breast and endometrial cancer cell lines. |
| Commentary on involvement of protein in cancer: | No mutations reported on the Atlas of Genetics in Oncology and only one mutated sample on the SANGER COSMIC database. |