Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | S100A13 |
| Gene Name: | S100A13 |
| Protein Full Name: | Protein S100-A13 |
| Alias: | S100 calcium binding protein A13; S100-A13; S10AD |
| Mass (Da): | 11471 |
| Number AA: | 98 |
| UniProt ID: | Q99584 |
| Locus ID: | 6284 |
| COSMIC ID: | S100A13 |
| Gene location on chromosome: | 1q21.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.09 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | S100A13 is a calcium-binding protein that plays a role in the export of proteins without a signalling peptide via an alternative pathway. It may be involved in cell cycle progression and differentiation similar to other family members. It is a marker of active angiogenesis in some tumors and may promote FGF1 and IL-1alpha secretion during intracellular stress conditions. It is overexpressed in lung cancer, endometriosis, and glioblastoma. |