Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | KLF6 |
| Gene Name: | KLF6 |
| Protein Full Name: | Krueppel-like factor 6 |
| Alias: | B-cell-derived protein 1;Core promoter element-binding protein;GC-rich sites-binding factor GBF;Proto-oncogene BCD1;Suppressor of tumorigenicity 12 protein;Transcription factor Zf9 |
| Mass (Da): | 31865 |
| Number AA: | 283 |
| UniProt ID: | Q99612 |
| Locus ID: | 1316 |
| COSMIC ID: | KLF6 |
| Gene location on chromosome: | 10p15.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20358 |
| Percent of cancer specimens with mutations: | 0.26 |
| Normal role description: | Activates genes involved in TGF-beta signalling, B-cell differentiation, and apoptosis. Loss of function promotes the development of cancer by impairing cellular ability to differentiate or commit to apoptosis. |