Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RAD9A |
| Gene Name: | RAD9A |
| Protein Full Name: | Cell cycle checkpoint control protein RAD9A |
| Alias: | DNA repair exonuclease rad9 homolog A |
| Mass (Da): | 42547 |
| Number AA: | 391 |
| UniProt ID: | Q99638 |
| Locus ID: | 5883 |
| COSMIC ID: | RAD9A |
| Gene location on chromosome: | 11q13.2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.2 |
| Normal role description: | After phoyphorylation Rad9A by PKC delta, it forms a checkpoint protein complex with RAD1 and HUS1 (9-1-1 complex) that is recruited by RAD17 replication factor C (RFC) clamp loader complex to the sites of DNA damage. Rad9A binds BCL2 and Bcl-x2 and thereby promotes apoptosis. It was suggested to recruit DNA polymerase beta to sites of DNA damage. Has 3'-5' exonuclease activity which could contribute to its role in sensing damaged DNA, though the exact function is unknown. Upregulated expression in many cancers. |