Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SDHC |
| Gene Name: | SDHC |
| Protein Full Name: | Succinate dehydrogenase cytochrome b560 subunit, m |
| Alias: | Integral membrane protein CII-3;QPs-1;Succinate dehydrogenase complex subunit C;Succinate-ubiquinone oxidoreductase cytochrome B large subunit |
| Mass (Da): | 18610 |
| Number AA: | 169 |
| UniProt ID: | Q99643 |
| Locus ID: | 6391 |
| COSMIC ID: | SDHC |
| Gene location on chromosome: | 1q21 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20262 |
| Percent of cancer specimens with mutations: | 0.08 |
| Mutations observed as inherited: | Hereditary paraganglioma type 3; Carney-Stratakis syndrome |
| Normal role description: | Subunit of succinate dehydrogenase (SDH) that functions as an anchor. SDH is involved in complex II of the mitochondrial electron transport chain. |