Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MAP3K5 |
| Gene Name: | MAP3K5 |
| Protein Full Name: | Mitogen-activated protein kinase kinase kinase 5 |
| Alias: | Apoptosis signal regulating kinase 1; Apoptosis signal-regulating kinase 1; ASK-1; Kinase ASK1; M3K5; MAP3K5; MAPK/ERK kinase kinase 5; MAPKKK5; MEK kinase 5; MEKK 5; MEKK5 |
| Mass (Da): | 154518 |
| Number AA: | 1374 |
| UniProt ID: | Q99683 |
| Locus ID: | 4217 |
| COSMIC ID: | MAP3K5 |
| Gene location on chromosome: | 6q23.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20474 |
| Percent of cancer specimens with mutations: | 0.97 |
| Normal role description: | MAP3K5 is a protein-serine/threonine kinase. Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death |