Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SLC29A1 |
| Gene Name: | SLC29A1 |
| Protein Full Name: | Equilibrative nucleoside transporter 1 |
| Alias: | Equilibrative NBMPR-sensitive nucleoside transporter; Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter; Nucleoside transporter, es-type; S29A1; Solute carrier family 29 member 1 |
| Mass (Da): | 50219 |
| Number AA: | 456 |
| UniProt ID: | Q99808 |
| Locus ID: | 2030 |
| COSMIC ID: | SLC29A1 |
| Gene location on chromosome: | 6p21.1-p21.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19688 |
| Percent of cancer specimens with mutations: | 0.38 |
| Normal role description: | Sodium-independent nucleoside transmembrane transporter. Mediates influx and efflux of nucleosides across the membrane (equilibrative transporter). It is important for the uptake of cytotoxic neucleosides, as used in cancer chemotherapy. |