Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | BAG1 |
| Gene Name: | BAG1 |
| Protein Full Name: | BAG family molecular chaperone regulator 1 |
| Alias: | Bcl-2-associated athanogene 1 |
| Mass (Da): | 38860 |
| Number AA: | 345 |
| UniProt ID: | Q99933 |
| Locus ID: | 573 |
| COSMIC ID: | BAG1 |
| Gene location on chromosome: | 9p13.3 |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.24 |
| Normal role description: | BCL2-associated athanogene (BAG1) binds to and thereby enhnaces the activity of BCL-2 -- an anti-apoptosis protein. BAG1 is one of the many mediators of growth factor receptor signalling and anti-apoptoic signalling. Upregulation of this gene has been observed in breast, colon, lung, prostate, and uterine tumors. |
| Commentary on involvement of protein in cancer: | Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli. |