Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CITED2 |
| Gene Name: | CITED2 |
| Protein Full Name: | Cbp/p300-interacting transactivator 2 |
| Alias: | MSG-related protein 1;P35srj |
| Mass (Da): | 28497 |
| Number AA: | 270 |
| UniProt ID: | Q99967 |
| Locus ID: | 10370 |
| COSMIC ID: | CITED2 |
| Gene location on chromosome: | 6q24.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR (no mutations found) |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.17 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | CITED2 is a nuclear transcriptional coactivator of the p300/CBP-mediated transcription complex. It links TFAP2 trasncription factors and the p300/CBP complex to stimulate TFAP2-mediated transcriptional activation, and can also enhance estrogen-dependent transactivation mediated by estrogen receptors. CITED2 can also positively regulate TGF-beta signalling via associations with the SMAD/p300/CBP complex and also stimulate the peroxisome proliferator-activated receptors (PPARA) transcriptional activity. In addition to its coactivator role, it can also act as a corepressor by interfering with the binding of HIF1A or STAT2 with the p300/CBP complex. Overactivity, mediated by CITED2 upregulation by bFBF and other factors, has been associated with malignancies. TGF-beta induced cell invasion could be reduced by downregulation of CITED2. Upregulation of CITED2 has also been shown to inhibit HIF-1 induced apoptosis. |