Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | VRK1 |
| Gene Name: | VRK1 |
| Protein Full Name: | Serine/threonine-protein kinase VRK1 |
| Alias: | EC 2.7.11.1; Serine/threonine protein kinase VRK1; vaccinia related kinase 1; Vaccinia-related kinase 1 |
| Mass (Da): | 45476 |
| Number AA: | 396 |
| UniProt ID: | Q99986 |
| Locus ID: | 7443 |
| COSMIC ID: | VRK1 |
| Gene location on chromosome: | 14q32.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19853 |
| Percent of cancer specimens with mutations: | 0.25 |
| Normal role description: | VRK1 is a serine/threonine protein kinase. Its targets are p53, c-JUN, ATF2 and BAF1. It is in regulation of cell proliferation and disassembley of Golgi during cell cycle. In cancer, overexpression is associated with survival signals and proliferation.cTranslocation events that occur around the gene has been seein in T-cell acute lymphoblastic leukemia. |