Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | GDF15 |
| Gene Name: | GDF15 |
| Protein Full Name: | Growth/differentiation factor 15 |
| Alias: | Macrophage inhibitory cytokine 1;NSAID-activated gene 1 protein;NSAID-regulated gene 1 protein;Placental TGF-beta;Placental bone morphogenetic protein;Prostate differentiation factor |
| Mass (Da): | 34154 |
| Number AA: | 308 |
| UniProt ID: | Q99988 |
| Locus ID: | 9518 |
| COSMIC ID: | GDF15 |
| Gene location on chromosome: | 19p13.11 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.24 |
| Normal role description: | Secreted glycoprotein with different cellular effects depending on the system. Attenuates TNF-a macrophage activation; activates MEK/ERK pathway; promotes apoptosis. Has been implicated in both oncogenesis (MEK/ERK) and also anti-oncogenesis (apoptosis) mechanisms |