Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MACROD1 |
| Gene Name: | MACROD1 |
| Protein Full Name: | MACRO domain-containing protein 1 |
| Alias: | Protein LRP16 |
| Mass (Da): | 35505 |
| Number AA: | 325 |
| UniProt ID: | Q9BQ69 |
| Locus ID: | 28992 |
| COSMIC ID: | MACROD1 |
| Gene location on chromosome: | 11q13.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19609 |
| Percent of cancer specimens with mutations: | 0.19 |
| Deregulated in translocations: | RUNX1 |
| Normal role description: | MACROD1 has many roles in the cell. It is involved in deacetylation of O-acetyl-ADP ribose, co-activation of estrogen receptor and androgen receptor, recruitment and activation of PARP1 during radiation induced DNA damage and enhance TNFa induced NF-kb activation. It is found overexpressed in various cancers and associated with cancer progression. Overexpression in cancers that use ER or AR results in growth advantage for androgen and estrogen dependent prostate, breast and endometrial cancers. |