Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | WDR77 |
| Gene Name: | WDR77 |
| Protein Full Name: | Methylosome protein 50 |
| Alias: | HKMT1069; MEP50; MGC2722; Nbla10071; RP11-552M11.3; WD repeat domain 77 |
| Mass (Da): | 36724 |
| Number AA: | 342 |
| UniProt ID: | Q9BQA1 |
| Locus ID: | 79084 |
| COSMIC ID: | WDR77 |
| Gene location on chromosome: | 1p13.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.15 |
| Normal role description: | WDR77 is a WD40 domain repeat containing protein found in the PRMT5 methyltransferase complex in the nucleus. WDR77 was found to interact histone H2A was may target the complex to histones. In prostate and testicular cancer WDR77 was found to translocate to the nucleus and act as a coactivator of the androgen-receptor. Activation of the androgen-receptor may promote cell growth and proliferation in cancer cells. |