Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | LZTS2 |
| Gene Name: | LZTS2 |
| Protein Full Name: | Leucine zipper putative tumor suppressor 2 |
| Alias: | KIAA1813; LAPSER1; Leucine zipper tumor suppressor 2; Leucine zipper, putative tumor suppressor 2; Protein LAPSER1 |
| Mass (Da): | 72759 |
| Number AA: | 669 |
| UniProt ID: | Q9BRK4 |
| Locus ID: | 84445 |
| COSMIC ID: | LZTS2 |
| Gene location on chromosome: | 10q24 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19688 |
| Percent of cancer specimens with mutations: | 0.48 |
| Normal role description: | Essential for spindle formation and completion of cytokinesis. Negatively regulates katanin-mediated microtubule severing and release from the centrosome. May negatively regulate axonal outgrowth. Negative regulator of the Wnt signalling pathway and repressor of beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. |