Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ARHGAP9 |
| Gene Name: | ARHGAP9 |
| Protein Full Name: | Rho GTPase-activating protein 9 |
| Alias: | 10C; MGC1295; RGL1; RHG09; Rho GTPase activating 9; Rho GTPase activating protein 9 |
| Mass (Da): | 83260 |
| Number AA: | 750 |
| UniProt ID: | Q9BRR9 |
| Locus ID: | 64333 |
| COSMIC ID: | ARHGAP9 |
| Gene location on chromosome: | 12q13.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.68 |
| Normal role description: | ARHGAP9 is a RHO GTPase activator. It induces RHO related G-proteins to catalyze GTP to GDP thus inactivating them and has been shown to regulate adhesion of hematopoietic cells to the extracellular matrix. It has also been involved with cross talk with MAPK pathway by acting as a docking protein via WW domain. |