Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MTA3 |
| Gene Name: | MTA3 |
| Protein Full Name: | Metastasis-associated protein MTA3 |
| Alias: | KIAA1266; metastasis associated 1 family, member 3; metastasis associated family, member 3; metastasis associated gene family, member 3; metastasis-associated protein MTA3 |
| Mass (Da): | 67504 |
| Number AA: | 594 |
| UniProt ID: | Q9BTC8 |
| Locus ID: | 57504 |
| COSMIC ID: | MTA3 |
| Gene location on chromosome: | 2p21 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBIT |
| Number of cancer specimens: | 19557 |
| Percent of cancer specimens with mutations: | 0.3 |
| General distribution of mutations: | Only 2 sites |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | MTA3 is a transcriptional regulator and plays a role in maintaining normal epithelial structure by repressing SNAIL transcription, the master regulator of epithelial-to-mesenchymal transition, and increasing E-cadherin levels in a deacetylase-dependent manner. Depressed expression promotes cell migration and dedifferentiation of epithelial cells. |