Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TRAF4 |
| Gene Name: | TRAF4 |
| Protein Full Name: | TNF receptor-associated factor 4 |
| Alias: | CART1; CART1, MLN62, RNF83, TNF receptor associated factor 4; Cysteine-rich domain associated with RING and Traf domains protein 1; Malignant 62; MLN62; RING finger protein 83; RNF83; TNF receptor-associated factor 4; TRA4 |
| Mass (Da): | 53543 |
| Number AA: | 470 |
| UniProt ID: | Q9BUZ4 |
| Locus ID: | 9618 |
| COSMIC ID: | TRAF4 |
| Gene location on chromosome: | 17q11-q12 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20150 |
| Percent of cancer specimens with mutations: | 0.22 |
| Normal role description: | TRAF4 is a member of the TNF receptor associated factor (TRAF) family.TRAF4 in known to interact with neurotrophin receptor, p75 (NTR/NTSR1), and it will negatively regulate NTR-induced cell death and NF-kappa B activation. Gene amplifications have been found in about 25% breast tumors. |