Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ADI1 |
| Gene Name: | ADI1 |
| Protein Full Name: | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygena |
| Alias: | Aci-reductone dioxygenase; Acireductone dioxygenase 1; APL1; ARD; FLJ10913; HMFT1638; Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1; MTCBP-1; MTND; SIPL |
| Mass (Da): | 21500 |
| Number AA: | 179 |
| UniProt ID: | Q9BV57 |
| Locus ID: | 55256 |
| COSMIC ID: | ADI1 |
| Gene location on chromosome: | 2p25.3 |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.11 |
| Normal role description: | ADl1 is a metallo aci-reductone dioxygenase enzyme involved in methionine salvage. This enzyme converts 1,2-dihydroxy-3-keto-5-(methylthio)pentene to 5'-methylthioadenosine and ultimately to methionine. 5'-methylthioadenosine is a potent inhibitor of polyamine biosynthesis. As polyamines are required for cell growth and proliferation dysfunction of ADl1 may have a role as a tumour suppressor protein. |