Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TRAIP |
| Protein Full Name: | Leucine-rich repeat flightless-interacting protein |
| Alias: | ring finger protein 206; RNF206; TRAF interacting protein; TRIP |
| Mass (Da): | 53294 |
| Number AA: | 808 |
| UniProt ID: | Q9BWF2 |
| Locus ID: | 10293 |
| Gene location on chromosome: | 3p21.31 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20339 |
| Percent of cancer specimens with mutations: | 0.33 |
| Normal role description: | RAIP is part of the receptor-TRAF signalling complex and binds TRAF1 and TRAF2. It inhibits the TNF-mediated activation of NFκB. |
| Commentary on involvement of protein in cancer: | 4/334 lung- and 1/59 ovarian tumour samples were also mutated (Sanger COSMIC) |