Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PAPPA2 |
| Gene Name: | PAPPA2 |
| Protein Full Name: | Pappalysin-2 |
| Alias: | PAP2; PAPP- E; PAPP2; PAPP-A2; Pappalysin-2; PLAC3; Placenta-specific 3; Pregnancy-associated plasma protein E1; Pregnancy-associated plasma protein-E |
| Mass (Da): | 198539 |
| Number AA: | 1791 |
| UniProt ID: | Q9BXP8/A9Z1Y8 |
| Locus ID: | 60676 |
| COSMIC ID: | PAPPA2 |
| Gene location on chromosome: | 1q23-q25 |
| Cancer protein type: | TSP (possibly) |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBIT (possibly) |
| Number of cancer specimens: | 19655 |
| Percent of cancer specimens with mutations: | 3.41 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | PAPPA2 is a metalloprotease that can specifically cleave IGFBP5 and decrease IGF signalling. It therefore may have tumour suppressor activity, but its function is still unclear. |
| Commentary on involvement of protein in cancer: | no entry in AGO; multiple uniprot ID for different isoforms |