Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | FUT8 |
| Gene Name: | FUT8 |
| Protein Full Name: | Alpha-(1,6)-fucosyltransferase |
| Alias: | Fucosyltransferase 8;GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase;GDP-fucose--glycoprotein fucosyltransferase;Glycoprotein 6-alpha-L-fucosyltransferase |
| Mass (Da): | 66516 |
| Number AA: | 575 |
| UniProt ID: | Q9BYC5 |
| Locus ID: | 2530 |
| COSMIC ID: | FUT8 |
| Gene location on chromosome: | 14q23.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.56 |
| Normal role description: | FUT8 is a fucosyltransferase that catalyzes the transfer of a fucose residue to the reducing end of an N-linked glycoprotein via a 1,6-linkage. FUT8 is a type II membrane protein localized to the trans golgi. Fucosylation is required for normal biological activity of various proteins including, TGFB1 receptor, EGF receptor and VEGF receptor. Increased activity or overexpression of FUT8 has been observed in hepatocellular, ovarian, thryoid, pancreatic and colorectal cancers. FUT8 expression is correlated with growth size and metastasis of tumours. Increased fucosylation of alpha-fetoprotein (AFP) in hepatocellular carcinoma and haptoglobin in pancreatic cancers are used as markers to diagnosis these cancers. FUT8 may contribute to the development of more aggressive forms of cancer and thus is classified as an oncogene. |